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KMID : 0351619700110010155
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Kyungpook Medical Journal
1970 Volume.11 No. 1 p.155 ~ p.160
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Studies on Lysosomal Acid Phosphatase in Ethionine Induced Cirrhotic Rat Liver
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金彩圭/Kim, Chae Kyoo
李熹完/崔日炯/朴成大/Lee, Hi Won/Park, Sung Dae/Choi, Il Hyung
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Abstract
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The changes in activities of liver lysosomal and cytoplasmic acid phosphatase, and osmotic fragility of lysosome isolated from liver of rats fed synthetic diet containing 0.25% DL-ethionine ::,for period of seven months have been eatamined.
Histological studies revealed moderate to severe cirrhotic change accompanied with fatty degeneration and cell neerosis in all cases. Certain histological features suggestive of malignancy were also presented in 3 rats out of 8 cases but evidence of biological nalignancy, such as invasion or metastis were not observed. Chemical etermination .revealed significant increa:;e in lipids and hydroxyproline content.
The activities of lysosomal and cytoplasmic acid phosphatase of the ethionine induced cirrhotic livers showed no noticeable alteration, butthe osmotic fragility of lysosome in vitro, dete-~ rmined from unbound acid phosphatase released`,.. in labilizing medium, showed a significant decrease.
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KEYWORD
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